Dual versus single energy cardiac CT to measure extracellular volume in cardiac amyloidosis: correlations with cardiac MRI

Autor: Anahita Tavoosi, Juliana Brenande de Oliveira Brito, Huda El Mais, Toby D. Small, Andrew M. Crean, Benjamin J.W. Chow, Gary R. Small
Jazyk: angličtina
Rok vydání: 2023
Předmět:
Zdroj: International Journal of Cardiology: Heart & Vasculature, Vol 44, Iss , Pp 101166- (2023)
Druh dokumentu: article
ISSN: 2352-9067
DOI: 10.1016/j.ijcha.2022.101166
Popis: Rationale and objectives: Determine in cardiac amyloid (CA) patients, whether cardiac CT derived extracellular volume (ECV) correlates with that obtained by MRI. Perform this correlation with single (SECT) versus dual energy (DECT) CT and evaluate whether a single sample volume ECV-measure was as reliable as a global (16 segment) assessment. Materials and methods: CA patients who had undergone a clinical cardiac MRI (CMR) were recruited prospectively. SECT and DECT cardiac scans were performed. Three ECG-triggered prospective SECT scans were acquired: non-contrast, arterial-phase contrast and 5-minute delayed images. A DECT scan was performed at 7 min. Post processing was used to determine ECV. Analyses of SECT or DECT global ECV versus CMR were performed using the Pearson correlation coefficient, Bland Altman analysis and Intraclass correlation coefficient (ICC). Similar analyses were performed to examine the performance of single-segment sampling by SECT or DECT versus CMR. Results: 25 patients were recruited, mean age was 80.0 ± 7.1 years, 80 % were male, 21 patients had transthyretin- CA, 4 had light chain- CA. Correlations were close with both SECT or DECT global ECV versus CMR (r = 0.79 and 0.88 respectively, p
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