| Autor: |
Alcina F Nicol, José R Lapa e Silva, Cynthia B Cunha, Sergio M Amaro-Filho, Nathalia Oliveira, Beatriz Grinsztejn, Ruth Khalili Friedman, Fabio Russomano, Andrea Pires, Jonathan E Golub, Gerard J Nuovo |
| Jazyk: |
angličtina |
| Rok vydání: |
2012 |
| Předmět: |
|
| Zdroj: |
PLoS ONE, Vol 7, Iss 4, p e32936 (2012) |
| Druh dokumentu: |
article |
| ISSN: |
1932-6203 |
| DOI: |
10.1371/journal.pone.0032936 |
| Popis: |
Minichromosome maintenance proteins (MCM) are highly expressed in actively replicating cells. The need for biological markers for cervical carcinoma and its precursor lesions is emerging. Our main aim was to determine the immunohistochemical expression of MCM-2 in HIV-positive and -negative dysplastic cervical specimens.Immunohistochemical analysis of MCM-2 was performed in a total of 352 cervical TMA specimens of normal control, low-grade CIN, high-grade CIN and invasive tumor. 38 specimens were from HIV-positive women. A receiver operating characteristic (ROC) curve was constructed to determine the best cutoff to diagnose high-grade CIN and invasive cervical cancer.In the progression from normal epithelium to high-grade CIN and invasive tumor we found significant differences in the MCM-2 expression (p |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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