Efficacy of Daratumumab‐Based Regimens for Extramedullary Pulmonary Plasmacytoma: A Case Report

Autor: Danilo De Novellis, Pio Zeppa, Elisabetta Maffei, Valentina Giudice, Carmine Selleri, Bianca Serio
Jazyk: angličtina
Rok vydání: 2024
Předmět:
Zdroj: Cancer Reports, Vol 7, Iss 11, Pp n/a-n/a (2024)
Druh dokumentu: article
ISSN: 2573-8348
DOI: 10.1002/cnr2.2149
Popis: ABSTRACT Introduction Multiple myeloma (MM) with pulmonary extramedullary disease is rare and usually associated with poor prognosis, and no data on daratumumab‐based regimens have been reported yet. Case Presentation Here, a 64‐year‐old man with pulmonary plasmacytoma received daratumumab‐based regimens and has achieved a very good partial response with lung mass disappearance and overall survival of 16 months. He did not receive autologous stem cell transplantation because of several comorbidities, such as severe drug‐induced neuropathy and JAK2‐mutated myeloproliferative neoplasm with marked splenomegaly. Conclusions We showed the efficacy of daratumumab in combination with targeted therapies for the treatment of pulmonary MM.
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