Hippocampal adult-born granule cells drive network activity in a mouse model of chronic temporal lobe epilepsy

Autor: F. T. Sparks, Z. Liao, W. Li, A. Grosmark, I. Soltesz, A. Losonczy
Jazyk: angličtina
Rok vydání: 2020
Předmět:
Zdroj: Nature Communications, Vol 11, Iss 1, Pp 1-13 (2020)
Druh dokumentu: article
ISSN: 2041-1723
DOI: 10.1038/s41467-020-19969-2
Popis: The dentate gyrus is involved in synchronous discharges and seizures, but its microcircuit functional organization in TLE is unclear. Here, the authors show that interictal discharges recruit specific granule cell ensembles dominated by adult-born immature neurons.
Databáze: Directory of Open Access Journals