Pharmacological interactions in novel oral anticoagulants, statins, and hypertension drugs in patients treated with direct-acting antivirals for hepatitis C: a Delphi Consensus project
| Autor: | Ivan Gentile, Giancarlo Agnelli, Angelo Avogaro, Claudio Borghi, Alessia Ciancio, Ernesto Claar, Patrizio Pasqualetti, Pasquale Perrone Filardi |
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| Jazyk: | angličtina |
| Rok vydání: | 2024 |
| Předmět: | |
| Zdroj: | Italian Journal of Medicine, Vol 18, Iss 4 (2024) |
| Druh dokumentu: | article |
| ISSN: | 1877-9344 1877-9352 |
| DOI: | 10.4081/itjm.2024.1846 |
| Popis: | To date, no retrospective or real-world studies have comprehensively examined the interactions between direct-acting antivirals (DAAs) and widely used medications such as novel oral anticoagulant, statins, and antihypertensive agents. However, clinical experience from key opinion leaders may guide physicians in managing these interactions in patients undergoing DAA treatment. This study aims to elucidate the interactions between DAAs and commonly prescribed drugs in patients with prevalent comorbidities (e.g., type II diabetes, hypertension, and dyslipidemia), with a particular focus on those receiving polytherapy with cardiovascular drugs while undergoing DAA treatment for hepatitis C. The clinicians’ experience was combined with input from a qualified expert panel using a Consensus Delphi approach. The findings of this study offer essential and practical recommendations that can be readily applied in everyday clinical practice, helping physicians in managing hepatitis C virus patients undergoing DAA therapy. |
| Databáze: | Directory of Open Access Journals |
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