| Autor: |
Rustum S. Boyce, Jonathan M. White, Andrew M. Bray, Ian W. James, Craig S. Sheehan, Thao Nguyen, Sharon T. Marino, Beata M. Krywult, Daniel A. Huggins, Peter G. Griffiths, Neil Choi, Danuta Stachurska-Buczek, Jack G. Parsons |
| Jazyk: |
angličtina |
| Rok vydání: |
2004 |
| Předmět: |
|
| Zdroj: |
Molecules, Vol 9, Iss 6, Pp 449-458 (2004) |
| Druh dokumentu: |
article |
| ISSN: |
1420-3049 |
| DOI: |
10.3390/90600449 |
| Popis: |
The synthesis of (2S)-2-benzyloxymethyl-3-(2-fluoro-4-methoxyphenyl)- propionic acid, (2S)-2-benzyloxymethyl-3-(2-fluoro-4-methylphenyl)propionic acid and (2S)-2-benzyl-oxymethyl-3-(2,4-dimethylphenyl)propionic acid has been achieved by TiCl4 mediated alkylation of the corresponding (4R)-4-benzyl-3-[3-(2-fluoro-4-methoxyphenyl-, 2-fluoro-4-methylphenyl-, 2,4- dimethylphenyl-)propionyl]-2-oxazolidinones, followed by hydrolysis of the chiral auxiliary. The stereochemistry of the alkylation reaction was confirmed by an X-ray crystal structure of (4R)-4-benzyl-3-[(2S)-2-benzyloxymethyl-3-(2- fluoro-4-methylphenyl)propionyl]-2-oxazolidinone. |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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