Heterogeneity between Ducts of the Same Nuclear Grade Involved by Duct Carcinoma (DCIS) of the Breast

Autor: Naomi A. Miller, Judith-Anne W. Chapman, Jin Qian, William A. Christens-Barry, Yuejiao Fu, Yan Yuan, H. Lavina A. Lickley, David E. Axelrod
Jazyk: angličtina
Rok vydání: 2010
Předmět:
Zdroj: Cancer Informatics, Vol 9 (2010)
Druh dokumentu: article
ISSN: 1176-9351
DOI: 10.4137/CIN.S5505
Popis: Purpose Nuclear grade of breast DCIS is considered during patient management decision-making although it may have only a modest prognostic association with therapeutic outcome. We hypothesized that visual inspection may miss substantive differences in nuclei classified as having the same nuclear grade. To test this hypothesis, we measured subvisual nuclear features by quantitative image cytometry for nuclei with the same grade, and tested for statistical differences in these features. Experimental design and statistical analysis Thirty-nine nuclear digital image features of about 100 nuclei were measured in digital images of H
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