6mer seed toxicity in tumor suppressive microRNAs
| Autor: | Quan Q. Gao, William E. Putzbach, Andrea E. Murmann, Siquan Chen, Aishe A. Sarshad, Johannes M. Peter, Elizabeth T. Bartom, Markus Hafner, Marcus E. Peter |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2018 |
| Předmět: | |
| Zdroj: | Nature Communications, Vol 9, Iss 1, Pp 1-16 (2018) |
| Druh dokumentu: | article |
| ISSN: | 2041-1723 78972507 |
| DOI: | 10.1038/s41467-018-06526-1 |
| Popis: | Small interfering (siRNAs) can be toxic to cancer cells. Here the authors investigate the toxicity of microRNA in cancer cells by performing a siRNA screen that tests the miRNA activities of an extensive list of miRNAs with different 6mer seed sequences. |
| Databáze: | Directory of Open Access Journals |
| Externí odkaz: |
|