Evaluation of Glucagon-Like Peptide 1 (GLP-1) Levels and Oxidative Stress in Preterm Infants
| Autor: | E Abbasi, F Pishbin, N Tahmasebpour Shahsavar, R Shahabi, ME Ghafari, S Tabatabai, S Heidari |
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| Jazyk: | English<br />Persian |
| Rok vydání: | 2022 |
| Předmět: | |
| Zdroj: | Majallah-i Dānishgāh-i ̒Ulūm-i Pizishkī-i Bābul, Vol 24, Iss 1, Pp 18-24 (2022) |
| Druh dokumentu: | article |
| ISSN: | 1561-4107 2251-7170 |
| Popis: | Background and Objective: Glucagon-like peptide 1 (GLP-1) has anti-diabetic, antioxidant and anti-inflammatory properties that change under different conditions. This peptide is known as a therapeutic target in diabetes and obesity. The aim of this study was to investigate the relationship between GLP-1 and oxidative stress in preterm infants. Methods: In this case-control study, 40 term and preterm infants (gestational age less than 37 weeks) were used. GLP-1 concentration was measured by ELISA. Total antioxidant capacity (TAC), total oxidant status (TOS) and uric acid concentration were measured. Findings: Serum GLP-1 level in preterm infants was significantly higher than term infants (p=0.003). Serum TAC level in preterm infants (973.16±235.53) was significantly lower than term infants (837.00±218.97) (p=0.006). Serum TOS level in preterm infants (65.46±33.52) was significantly higher than term infants (31.50±14.62) (p |
| Databáze: | Directory of Open Access Journals |
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