Α-Lipoic Acid Ameliorates The Changes In Prooxidant-Antioxidant Balance In Liver And Brain Tissues Of Propylthiouracil- Induced Hypothyroid Rats
| Autor: | Adile Merve Baki, Abdurrahman Fatih Aydın, Pervin Vural, Vakur Olgaç, Semra Doğru Abbasoğlu, Müjdat Uysal |
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| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: | |
| Zdroj: | Cell Journal, Vol 22, Iss suppl 1, Pp 117-124 (2020) |
| Druh dokumentu: | article |
| ISSN: | 2228-5806 2228-5814 |
| DOI: | 10.22074/cellj.2020.7049 |
| Popis: | Objective There are controversial data about the prooxidant-antioxidant balance in hypothyroidism. We aimed to investigate the effect of α-lipoic acid (ALA) on oxidative stress parameters in the liver and brain of propylthiouracil (PTU)-induced hypothyroid rats. Materials And Methods In this experimental study, PTU (500 mg/L) was given to rats in drinking water for 10 weeks. ALA (0.2% in diet) alone and together with thyroxine (T4, 20 µg/kg body weight, s.c) were given to hypothyroid rats in the last 5 weeks of the experimental period. The levels of reactive oxygen species, malondialdehyde, protein carbonyl, ferric reducing antioxidant power (FRAP) and glutathione (GSH) levels, superoxide dismutase, and GSH peroxidase activities were determined in the liver and brain of rats. Histopathological examinations were also performed. Results Prooxidant parameters were increased in the brain but not liver in hypothyroid rats. ALA treatment alone lowered enhanced brain oxidative stress in hypothyroid rats. Also, ALA was found to ameliorate the changes as a result of oxidative stress arising from T4 replacement therapy. Conclusion Our results indicate that ALA alone and together with T4 may be useful in reducing oxidative stress in thyroid dysfunctions. |
| Databáze: | Directory of Open Access Journals |
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