| Autor: |
Adel Amer, Abdelrahman H. Hegazi, Mohammed Khalil Alshekh, Hany E. A. Ahmed, Saied M. Soliman, Antonin Maniquet, Rona R. Ramsay |
| Jazyk: |
angličtina |
| Rok vydání: |
2020 |
| Předmět: |
|
| Zdroj: |
Royal Society Open Science, Vol 7, Iss 4 (2020) |
| Druh dokumentu: |
article |
| ISSN: |
2054-5703 |
| DOI: |
10.1098/rsos.200050 |
| Popis: |
A new series of N'-substituted benzylidene-2-(4-oxo-2-phenyl-1,4-dihydroquinazolin-3(2H)-yl)acetohydrazide (5a–5h) has been synthesized, characterized by FT-IR, NMR spectroscopy and mass spectrometry and tested against human monoamine oxidase (MAO) A and B. Only (4-hydroxy-3-methoxybenzylidene) substituted compounds gave submicromolar inhibition of MAO-A and MAO-B. Changing the phenyl substituent to methyl on the unsaturated quinazoline ring (12a–12d) decreased inhibition, but a less flexible linker (14a–14d) resulted in selective micromolar inhibition of hMAO-B providing insight for ongoing design. |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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