| Autor: |
Haruta Rumi, Masumoto Norio, Emi Akiko, Sasada Tatsunari, Kajitani Keiko, Kobayashi Yoshie, Kadoya Takayuki, Shigematsu Hideo, Kataoka Tsuyoshi, Oda Miyo, Arihiro Kouji, Okada Morihito |
| Jazyk: |
angličtina |
| Rok vydání: |
2011 |
| Předmět: |
|
| Zdroj: |
World Journal of Surgical Oncology, Vol 9, Iss 1, p 146 (2011) |
| Druh dokumentu: |
article |
| ISSN: |
1477-7819 |
| DOI: |
10.1186/1477-7819-9-146 |
| Popis: |
Abstract We report a case of HER-2-positive recurrent breast cancer showing a clinically complete response to trastuzumab-containing chemotherapy 6 years after primary treatment of triple-negative breast cancer. The primary tumor was negative for HER-2 as determined by immunohistochemistry (IHC) and fluorescence in situ hybridization (FISH) (1+, and ratio, 1.1), but examination of the recurrent lymph node metastasis showed positivity for HER-2 by FISH (ratio, 5.2). No lesions were detected in either her left breast or in other organs, and the patient was diagnosed as having HER-2-positive recurrent disease. Combination chemotherapy using weekly paclitaxel and trastuzumab was initiated, and a clinically complete response was achieved. This report suggests the benefit of routine evaluation of HER-2 status in recurrent breast cancer with the introduction of HER-2-targeting agents. |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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