| Autor: |
John Kehinde Amoo, Akeem Abiodun Akindele, Abimbola Oladipupo Joseph Amoo, Akinwale Michael Efunshile, Taiwo Adetola Ojurongbe, Samuel Adetona Fayemiwo, Bolaji Nun Thomas, Olusola Ojurongbe |
| Jazyk: |
English<br />French |
| Rok vydání: |
2018 |
| Předmět: |
|
| Zdroj: |
The Pan African Medical Journal, Vol 30, Iss 66 (2018) |
| Druh dokumentu: |
article |
| ISSN: |
1937-8688 |
| DOI: |
10.11604/pamj.2018.30.66.13160 |
| Popis: |
INTRODUCTION: Enteric parasitic infections have been increasingly recognized as etiology of life-threatening chronic diarrhea in PLWHA in sub-Saharan Africa. This study investigated the prevalence and burden of intestinal parasitic infection among PLWHA in Abeokuta, southwest Nigeria. METHODS: freshly passed stool samples were collected from PLWHA. Detection of Cryptosporidium spp and Microsporidium spp was carried out with Kinyoun's stain and Weber's Chromotrope-based stain respectively. Investigation of other intestinal parasites was done using the direct saline preparation and formol-ether concentration methods. CD4+ T cell count was measured using Partec flow cytometry technique. RESULTS: a total of 231 (males: females 96:135; mean age 31.81,11.40 years) PLWHA were recruited into the study, among whom 84 (36.4%) were infected with at least one intestinal parasites. Fifty two (22.5%) individuals were positive for Cryptosporidium spp and a significant association between Cryptosporidium spp and diarrhea was observed (p=0.006). Seven (3.0%) were positive for Microsporidium spp. Helminths recovered included Ascaris lumbricoides (20.8%), hookworm (6.5%), Strongyloides stercoralis (4.3%), Trichuris trichiura (5.6%) and Taenia spp. (5.6%). Cryptosporidium spp, Microsporidium spp and S. stercoralis were significantly associated with CD4+ count 200 cells/mm3 (p=0.05). Cryptosporidium spp and A. lumbricoides were significantly observed among patients that are anti-retroviral therapy (ART) naive. CONCLUSION: high prevalence of opportunistic parasitic infection was significantly correlated with diarrhea, low CD4+ count and ART naïve individuals in the study. These findings re-emphasize the need for early diagnosis of opportunistic parasites and appropriate intervention among PLWHA. |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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