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Pavlov S. B., Pavlova G. B., Veligotsky A. N., Zukow W. Features cytokine profile in patients with pathological processes in obstuktivnymi pancreatoduodenal area in terms of reactions of functional system for damage connective tissue = Особенности цитокинового профиля у больных с обстуктивными патологическими процессами в панкреатодуоденальной зоне с точки зрения реакции функциональной системы соединительной ткани на повреждение. Journal of Education, Health and Sport. 2016;6(7):610-629. eISSN 2391-8306. DOI http://dx.doi.org/10.5281/zenodo.60045 http://ojs.ukw.edu.pl/index.php/johs/article/view/3744 The journal has had 7 points in Ministry of Science and Higher Education parametric evaluation. Part B item 755 (23.12.2015). 755 Journal of Education, Health and Sport eISSN 2391-8306 7 © The Author (s) 2016; This article is published with open access at Licensee Open Journal Systems of Kazimierz Wielki University in Bydgoszcz, Poland Open Access. This article is distributed under the terms of the Creative Commons Attribution Noncommercial License which permits any noncommercial use, distribution, and reproduction in any medium, provided the original author(s) and source are credited. This is an open access article licensed under the terms of the Creative Commons Attribution Non Commercial License (http://creativecommons.org/licenses/by-nc/4.0/) which permits unrestricted, non commercial use, distribution and reproduction in any medium, provided the work is properly cited. This is an open access article licensed under the terms of the Creative Commons Attribution Non Commercial License (http://creativecommons.org/licenses/by-nc/4.0/) which permits unrestricted, non commercial use, distribution and reproduction in any medium, provided the work is properly cited. The authors declare that there is no conflict of interests regarding the publication of this paper. Received: 02.07.2016. Revised 25.07.2016. Accepted: 28.07.2016. FEATURES cytokine profile in patients with pathological processes in OBSTUKTIVNYMI PANCREATODUODENAL AREA IN TERMS OF REACTIONS OF FUNCTIONAL SYSTEM FOR DAMAGE connective tissue S. B. Pavlov, G. B. Pavlova, A. N. Veligotsky, W. Zukow Kharkiv Medical Academy of Postgraduate Education Харьковская медицинская академия последипломного образования WKFZIT, UKW, Bydgoszcz, Poland Summary Introduction. Reducing the risk of postoperative complications - one of the most pressing problems in surgical practice. Any operation is accompanied by local and systemic response to surgical trauma. In the implementation of this response one of the key parts of a functional state of connective tissue (CT) and its response to the damage. Among surgical diseases occupy a prominent position obstructive pathological processes pancreatoduodenal zone (PDZ), characterized by a large number of complications. The goal was to increase the effectiveness of the prevention of complications in patients with obstruction of PDZ, which require prompt intervention, by taking into account FSCT state by determining cytokine markers. Materials and Methods: The study involved 133 patients with obstructive diseases PDZ. All patients were divided into three groups depending on the presence and severity of postoperative complications. 1 group with no or minimum weight of the complications included 66 (49.6%) patients, 2 group with complications of average weight - 52 (39.1%) patients, group 3 with severe systemic complications or death - 15 (11,3% ) patients. Determines the content of serum cytokines: (IL) 1β, 2, 4, 6, 8, TNFa; antibodies to prostate tissue by enzyme immunoassay, antibodies against atypical forms of collagen (ATAFK (IgG)). The study established that indicators of IL-1β in all the groups before surgery were elevated relative to the norm, most pronounced in patients 2 groups. There was a significant difference of preoperative baseline parameters between the groups (p |
