The role of the innate immune system in the development and treatment of hepatocellular carcinoma

Autor:	Christoph Roderburg, Alexander Wree, Münevver Demir, Moritz Schmelzle, Frank Tacke
Jazyk:	angličtina
Rok vydání:	2020
Předmět:	checkpoint inhibition HCC hepatocellular carcinoma immunotherapy innate immune system macrophages Diseases of the digestive system. Gastroenterology RC799-869 Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
Zdroj:	Hepatic Oncology, Vol 7, Iss 1 (2020)
Druh dokumentu:	article
ISSN:	2045-0931 2045-0923
DOI:	10.2217/hep-2019-0007
Popis:	Hepatocellular carcinoma (HCC) is the most common primary liver cancer. Most patients present with advanced or metastatic HCC at diagnosis and face a dismal prognosis. Tyrosine kinases are the gold standard treatment for this disease but yield limited survival benefits. Immune checkpoint inhibitors that augment adaptive immunity have been tested in HCC. Complex interactions between tumor cells, lymphocytes and the tumor environment determine the efficacy of such immunotherapies. Innate immune mechanisms – known drivers of liver disease progression in pre-HCC conditions such as fibrosis or cirrhosis – may either support or counteract tumor-related immune activation. In this review, we will highlight current concepts of the role of the innate immune system in hepatocarcinogenesis and discuss their relevance for translation into clinics.
Databáze:	Directory of Open Access Journals
Externí odkaz:	https://doaj.org/article/75841ad628bb4212af0ee4d5d1cfdc04 Zobrazit plný text záznamu View record in DOAJ