Mutually exclusive driver mutations identifies 2 separate primaries in a collision tumor initially interpreted as a solitary lung adenocarcinoma with tumor heterogeneity

Autor: Mary M. Torrez, Khalil Sheibani, Mohammad A. Vasef
Jazyk: angličtina
Rok vydání: 2024
Předmět:
Zdroj: Respiratory Medicine Case Reports, Vol 47, Iss , Pp 101986- (2024)
Druh dokumentu: article
ISSN: 2213-0071
DOI: 10.1016/j.rmcr.2024.101986
Popis: Distinction of histologically heterogenous, single primary tumor from two or more collision tumors with different primaries could represent a challenge to practicing pathologists. Histologic variations including differences in degree of differentiating within a tumor, are typically interpreted as tumor heterogeneity in a contiguous small size tumor biopsy. The authors report a case of adult former smoker female who presented with lung mass and a metastatic lytic lesion of acetabulum. A needle biopsy of a lung mass revealed an adenocarcinoma with well and moderately differentiated components. Next generation sequencing studies proved 2 different primaries in this small needle biopsy.
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