Structural basis of seamless excision and specific targeting by piggyBac transposase

Autor: Qiujia Chen, Wentian Luo, Ruth Ann Veach, Alison B. Hickman, Matthew H. Wilson, Fred Dyda
Jazyk: angličtina
Rok vydání: 2020
Předmět:
Zdroj: Nature Communications, Vol 11, Iss 1, Pp 1-14 (2020)
Druh dokumentu: article
ISSN: 2041-1723
DOI: 10.1038/s41467-020-17128-1
Popis: PiggyBac is a transposon used in genome engineering that does not leave excision footprints. Here the authors determine the structures of two complexes in which the piggyBac transposase is bound to DNA representing different steps of the transposition reaction, providing a basis for how the transposition reaction proceeds.
Databáze: Directory of Open Access Journals