| Autor: |
Usunomena Usunobun, Onotse Agunu, Benjamin Okechukwu |
| Jazyk: |
angličtina |
| Rok vydání: |
2024 |
| Předmět: |
|
| Zdroj: |
Journal of Research in Applied and Basic Medical Sciences, Vol 10, Iss 3, Pp 256-265 (2024) |
| Druh dokumentu: |
article |
| ISSN: |
2717-0098 |
| Popis: |
Background & Aims: Doxorubicin is a widely used antineoplastic agent for the treatment of solid tumors but its use is limited by its several severe tissue and organ toxicities. This study investigated changes in liver and spleen as a result of toxicity produced by Doxorubicin and the protective role of aqueous leaf extract of J. Tanjorensis. Materials & Methods: In this experimental study, rats were divided into 5 groups as follows: Group 1 served as control and orally received normal saline once daily. Doxorubicin (15 mg/kg) was administered to Group 2 from day 10. Group 3 received J. Tanjorensis (300 mg/kg, orally) once daily for 12 days. Group 4 received J. Tanjorensis (300 mg/kg, orally) once daily for 12 days and Doxorubicin (15 mg/kg) from day 10. Group 5 received Vitamin C (100 mg/kg, orally) once daily for 12 days, and Doxorubicin (15 mg/kg) from day 10. Doxorubicin administration was done intraperitoneally for three consecutive days. Sera samples were collected and used to assess liver function enzymes and synthetic molecules. Liver and spleen tissues were used to examine histopathological analysis. Data were analyzed by SPSS v.20 at a significance level of P |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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