Mediational pathways among drug use initiation, use-related consequences, and quit attempts

Autor: Adura Sogbesan, Danielle Lenz, Jamey J. Lister, Leslie H. Lundahl, Mark K. Greenwald, Eric A. Woodcock
Jazyk: angličtina
Rok vydání: 2024
Předmět:
Zdroj: Drug and Alcohol Dependence Reports, Vol 11, Iss , Pp 100229- (2024)
Druh dokumentu: article
ISSN: 2772-7246
DOI: 10.1016/j.dadr.2024.100229
Popis: Background: Factors that predict attempts to discontinue drug use are clinically relevant and may inform treatment. This study investigated drug use-related consequences as a predictor of drug quit attempts and treatment seeking among two cohorts of persons who use drugs. Methods: Drug use and clinical characteristics were assessed among persons who use cocaine (N=176; urine-verified; ‘Cocaine Cohort’) and among those who use heroin (N=166; urine-verified; ‘Heroin Cohort’). Mediation analyses assessed relationships among age at initial drug use, adverse drug-specific use-related consequences, and drug-specific quit attempts, separately for each cohort. Forward conditional logistic regression models evaluated drug use and clinical symptom scores as predictors of drug-specific treatment seeking. Results: Controlling for age, mediation models showed that drug use consequences fully mediated the relationship between age at initial drug use and number of drug-specific quit attempts for the ‘Cocaine Cohort’ and ‘Heroin Cohort’ (R2=0.30, p
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