| Autor: |
Micheska Epola Dibamba Ndanga, Jabar Babatundé Pacome Achimi Agbo Abdul, Jean Ronald Edoa, Guy Arnault Rogue Mfoumbi Ibinda, Bayodé Romeo Adegbite, Rhett Chester Mevyann, Christopher Mebiame Biyogho, Jocelyn Mahoumbou, Stredice Manguinga, Nina Mbenga Roguet, Bertrand Lell, Peter Gottfried Kremsner, Abraham Sunday Alabi, Martin Peter Grobusch, Ayola Akim Adegnika |
| Jazyk: |
angličtina |
| Rok vydání: |
2023 |
| Předmět: |
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| Zdroj: |
BMC Infectious Diseases, Vol 23, Iss 1, Pp 1-7 (2023) |
| Druh dokumentu: |
article |
| ISSN: |
1471-2334 |
| DOI: |
10.1186/s12879-023-08617-x |
| Popis: |
Abstract Background Non-tuberculous mycobacteria (NTM) are a group of bacteria that cause rare lung infections and are increasingly recognized as causative agents of opportunistic and device-associated infections in humans. In Gabon, there is a lack of data on NTM species identification and drug susceptibility. The aim of this study was to identify the frequency of NTM species and their genotypic susceptibility pattern to commonly used antibiotics for NTM infections in Gabon. Methods A cross-sectional study was conducted at the CERMEL TB laboratory from January 2020 to December 2022, NTM subspecies identification and drug susceptibility testing to macrolides and aminoglycosides were performed using the genotype NTM-DR kit. Results The study found that out of 524 culture-positive specimens, 146 (28%) were NTM, with the predominant group being Mycobacterium avium complex (MAC) and Mycobacterium abscessus complex (MABC). All MAC isolates were fully susceptible to macrolides and aminoglycosides, while five MABC isolates carried mutations indicative of reduced susceptibility to macrolide and aminoglycoside drugs. Conclusions These findings suggest that clinicians may use macrolides and aminoglycosides to manage NTM infections caused by MAC, but further investigation is required to determine MABC drug susceptibility. |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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