| Autor: |
Pongor Sándor, Ivanova Neli, Popovic Matija, De Biasio Alfredo, Pintar Alessandro |
| Jazyk: |
angličtina |
| Rok vydání: |
2007 |
| Předmět: |
|
| Zdroj: |
Biology Direct, Vol 2, Iss 1, p 19 (2007) |
| Druh dokumentu: |
article |
| ISSN: |
1745-6150 |
| DOI: |
10.1186/1745-6150-2-19 |
| Popis: |
Abstract The cytoplasmic tail of Notch ligands drives endocytosis, mediates association with proteins implicated in the organization of cell-cell junctions and, through regulated intra-membrane proteolysis, is released from the membrane as a signaling fragment. We survey these findings and discuss the role of Notch ligands intracellular region in bidirectional signaling and possibly in signal modulation in mammals. Reviewers This article was reviewed by Frank Eisenhaber, L Aravind, and Eugene V. Koonin. |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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