Comparison of third and second generation parathyroid hormone assays and their use in chronic hemdialysis patients
| Autor: | Alexis Muryan, Mariana Dicugno, Mariano Forrester, Eduardo González de Sampaio, Mirta Alonso, Hernán Trimarchi |
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| Jazyk: | Spanish; Castilian |
| Rok vydání: | 2017 |
| Předmět: | |
| Zdroj: | Revista de Nefrología, Diálisis y Trasplante, Vol 34, Iss 1, Pp 8-12 (2017) |
| Druh dokumentu: | article |
| ISSN: | 0326-3428 2346-8548 |
| Popis: | Introduction: This work’s objective is to compare third and second generation assays in patients with normal kidney function and in chronic hemodialysis patients, and the implications on the latter. Methods: 60 chronic hemodialysis patients and 40 patients with normal kidney function were studied and their PTH levels were measured for both assays. Results: In patients population with normal kidney function the average on PTH was 51.8 and 45.6 pg/ml with second and third generation assays respectively. In chronic hemodialysis patients the average PTH was 193.9 and 137.1 pg/ml with second and third generation assays respectively. The difference between assays was 11.3% and 29.3% in patients with normal kidney function and in hemodialysis patients respectively. Third generation assay caused a variation in the amount of patients that fall over seve ral PTH ranges according to KDIGO guidelines, for a lesser value of 2 times the reference upper limit: it changes from 20 to 25 patients, between 2 and 9 times: it changes from 31 to 32 patients, and more than 9 times: it changes from 9 to 3 patients. Conclusions: When PTH concentration increases the difference between both assays also increases, for this reason we cannot use them indiscriminately in a chronic hemodialysis patient population. With third generation assays 11 patients (18.3%) changed their classification according to KDIGO guidelines, which will result in a change of treatment. |
| Databáze: | Directory of Open Access Journals |
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