The interconnected roles of TRIM21/Ro52 in systemic lupus erythematosus, primary Sjögren’s syndrome, cancers, and cancer metabolism

Autor:	Chueh-Hsuan Hsu, Yung-Luen Yu
Jazyk:	angličtina
Rok vydání:	2023
Předmět:	TRIM21/Ro52 Anti-Ro52 antibody Systemic lupus erythematosus Primary Sjögren’s syndrome Cancer immunology Cancer metabolism Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282 Cytology QH573-671
Zdroj:	Cancer Cell International, Vol 23, Iss 1, Pp 1-12 (2023)
Druh dokumentu:	article
ISSN:	1475-2867
DOI:	10.1186/s12935-023-03143-x
Popis:	Abstract Protein tripartite motif-containing 21 (TRIM21/Ro52), an E3 ubiquitin ligase, is an essential regulator of innate immunity, and its dysregulation is closely associated with the development of autoimmune diseases, predominantly systemic lupus erythematosus (SLE) and primary Sjögren’s syndrome (pSS). TRIM21 /Ro52 also features anti-cancer and carcinogenic functions according to different malignancies. The interconnected role of TRIM21/Ro52 in regulating autoimmunity and cell metabolism in autoimmune diseases and malignancies is implicated. In this review, we summarize current findings on how TRIM21/Ro52 affects inflammation and tumorigenesis, and investigate the relationship between TRIM21/Ro52 expression and the formation of lymphoma and breast cancer in SLE and pSS populations.
Databáze:	Directory of Open Access Journals
Externí odkaz:	https://doaj.org/article/721f4f25e63f4d82b7aeef6bc0ad23a2 Zobrazit plný text záznamu View record in DOAJ Plný text ve formátu PDF Plný text ve formátu HTML
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