A New Random Positioning Machine Modification Applied for Microgravity Simulation in Laboratory Experiments with Rats

Autor: Viktor V. Yotov, Jivka Marovska, Valentin Turiyski, Stoil I. Ivanov
Jazyk: angličtina
Rok vydání: 2022
Předmět:
Zdroj: Inventions, Vol 7, Iss 3, p 85 (2022)
Druh dokumentu: article
ISSN: 2411-5134
DOI: 10.3390/inventions7030085
Popis: The study presents a newly constructed modification of a random positioning machine (RPM) used in 3D-clinostat and in random mode. The main purpose is to provide an RPM animal model that uses up to four experimental animals simultaneously. In order to validate our RPM, the gravity dispersion and its magnitude are compared with the ones of a traditional machine. The results showed no crucial deviations in gravity dispersion and its time-averaged value in all sets of parameters. Furthermore, a posteriori stress tests are conducted on three Wistar male rats groups in order to estimate the level of stress from the setup. The social trait results suggest that the group exposed to our device has no increase in anxiety.
Databáze: Directory of Open Access Journals