Nuclear calcium signaling: a cell within a cell
| Autor: | M.A. Rodrigues, D.A. Gomes, M.H. Nathanson, M.F. Leite |
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| Jazyk: | angličtina |
| Rok vydání: | 2009 |
| Předmět: | |
| Zdroj: | Brazilian Journal of Medical and Biological Research, Vol 42, Iss 1, Pp 17-20 (2009) |
| Druh dokumentu: | article |
| ISSN: | 0100-879X 1414-431X |
| Popis: | Calcium (Ca2+) is a versatile second messenger that regulates a wide range of cellular functions. Although it is not established how a single second messenger coordinates diverse effects within a cell, there is increasing evidence that the spatial patterns of Ca2+ signals may determine their specificity. Ca2+ signaling patterns can vary in different regions of the cell and Ca2+ signals in nuclear and cytoplasmic compartments have been reported to occur independently. No general paradigm has been established yet to explain whether, how, or when Ca2+ signals are initiated within the nucleus or their function. Here we highlight that receptor tyrosine kinases rapidly translocate to the nucleus. Ca2+ signals that are induced by growth factors result from phosphatidylinositol 4,5-bisphosphate hydrolysis and inositol 1,4,5-trisphosphate formation within the nucleus rather than within the cytoplasm. This novel signaling mechanism may be responsible for growth factor effects on cell proliferation. |
| Databáze: | Directory of Open Access Journals |
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