| Autor: |
Minghua Hong, Junqing Wu, Lifeng Ma, Xiaoping Han, Ting Lu, Zhaoming Wang, Jing Zhao, Lizhen Liu, Huarui Fu, Weijia Huang, Weiyan Zheng, Jingsong He, Guoqing Wei, Huanping Wang, Zhimei Chen, He Huang, Zhen Cai, Guoji Guo, Jie Sun |
| Jazyk: |
angličtina |
| Rok vydání: |
2021 |
| Předmět: |
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| Zdroj: |
Biomarker Research, Vol 9, Iss 1, Pp 1-5 (2021) |
| Druh dokumentu: |
article |
| ISSN: |
2050-7771 |
| DOI: |
10.1186/s40364-021-00304-w |
| Popis: |
Abstract Myelodysplastic syndrome with myelofibrosis (MDS-MF) has been associated with an inferior prognosis compared with MDS without MF. However, MDS-MF is not listed independently as a subtype of MDS, and its clinical and genetic characteristics remain poorly understood. We retrospectively compared 53 patients with MDS-MF (44 MF grade 1/MF1; 9 MF grade 2–3/MF2 − 3) and 31 with de novo MDS without MF (MDS). The leukemic transformation risks of both MDS-MF2 − 3 and MDS-MF1 were increased compared with the MDS group. To identify the potential mechanisms responsible for the leukemic transformation of MDS-MF, we performed single-cell sequencing for one MDS-MF2 − 3 patient before and after leukemic transformation to explore the variations in gene expression levels. In addition to upgraded expression levels of acute myeloid leukemia-related genes during leukemic transformation, expression levels of some inflammation-related genes (such as S100s, RNASE3, and CYBB) were also increased, and inflammation-related pathways were up-regulated. These results suggest that inflammation-related genes and pathways may play an important role in the leukemic transformation of MDS-MF. |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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