Short tandem repeats genotyping of gestational choriocarcinoma – our experiences
| Autor: | Lajos Gergely, Vanda Repiska, Robert Petrovic, Miroslav Korbel, Ludovit Danihel, Jozef Sufliarsky, Michaela Kubickova, Helena Gbelcova, Petra Priscakova |
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| Jazyk: | angličtina |
| Rok vydání: | 2024 |
| Předmět: | |
| Zdroj: | Taiwanese Journal of Obstetrics & Gynecology, Vol 63, Iss 1, Pp 73-76 (2024) |
| Druh dokumentu: | article |
| ISSN: | 1028-4559 45563950 |
| DOI: | 10.1016/j.tjog.2023.10.004 |
| Popis: | Objective: This short communication demonstrates how short tandem repeat genotyping can identify the origin of gestational choriocarcinoma. Materials and methods: The origin of gestational choriocarcinoma in our three cases was determined using the short tandem repeats genotyping technique, which involved quantitative fluorescent PCR and fragmentation analysis. Results: In Case 1 despite no medical history of molar pregnancy, DNA analysis indicated that the choriocarcinoma originated from a homozygous complete hydatidiform mole. We conclude, that the patient's complete abortion 10 years prior to the choriocarcinoma diagnosis was an undiagnosed complete hydatidiform mole. In Case 2 and Case 3 the clinically presumed origin of choriocarcinoma was confirmed. Conclusion: Determining the origin of choriocarcinoma is essential for clinical application, as it affects the FIGO scoring system for gestational trophoblastic neoplasia, which determines the patient's prognosis and treatment approach. |
| Databáze: | Directory of Open Access Journals |
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