Urinary Biopterin Levels and Blood Dihydropteridine Reductase Activities in Patients with Thyroid and Breast Disorders
| Autor: | Girgin Gözde, Baydar Terken, Sahin Tevfik Tolga, Palabiyik Saziye Sezin, Sipahi Hande, Yuksel Osman, Tekin Ercüment, Taneri Ferit |
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| Jazyk: | angličtina |
| Rok vydání: | 2010 |
| Předmět: | |
| Zdroj: | Pteridines, Vol 21, Iss 1, Pp 72-78 (2010) |
| Druh dokumentu: | article |
| ISSN: | 0933-4807 2195-4720 |
| DOI: | 10.1515/pteridines.2010.21.1.72 |
| Popis: | Biopterin as a stable metabolite is produced by oxidation of 5,6,7,8-tetrahydrobiopterin (BH4). It is known that many diseases may cause changes in BH4 concentration and/or dihydropteridine reductase (DHPR) enzyme activity. There is only a limited number of studies correlating DHPR activity in malignancies. The main goal of the present study was to evaluate alterations in the DHPR activity and biopterin levels in patients with breast and thyroid cancers. The breast cancer patients (n=24) were compared to patients with benign breast diseases (n=19) and controls (n=30). In addition; the patients with thyroid cancer (n=17) were compared to patients with benign thyroid diseases (n=42) and the control group. We did not observe any significant difference between the benign disorders and the malignancies. Biopterin concentrations in patients with benign and malign thyroid and breast diseases were lower than the controls (all p |
| Databáze: | Directory of Open Access Journals |
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