The Role of Zinc and Copper in Platelet Activation and Pathophysiological Thrombus Formation in Patients with Pulmonary Embolism in the Course of SARS-CoV-2 Infection

Autor: Monika Szewc, Agnieszka Markiewicz-Gospodarek, Aleksandra Górska, Zuzanna Chilimoniuk, Mansur Rahnama, Elżbieta Radzikowska-Buchner, Karolina Strzelec-Pawelczak, Jarosław Bakiera, Ryszard Maciejewski
Jazyk: angličtina
Rok vydání: 2022
Předmět:
Zdroj: Biology, Vol 11, Iss 5, p 752 (2022)
Druh dokumentu: article
ISSN: 2079-7737
DOI: 10.3390/biology11050752
Popis: To date, many studies have proved that COVID-19 increases the incidence of thrombus formation and coagulopathies but the exact mechanism behind such a disease outcome is not well known. In this review we collect the information and discuss the pathophysiology of thrombus formation in patients with pulmonary embolism in the course of COVID-19 disease and the role of zinc and copper in the process. Supplementation of zinc and copper may be beneficial for COVID-19 patients due to its anti-inflammatory and anti-oxidative properties. On the other hand, excess of those microelements in the organism may be harmful, that is why marking the level of those micronutrients should be done at first. We also propose further investigation of diagnostic and therapeutic options of zinc and copper in course of COVID-19 thrombus formation to their potential in patient care, with particular emphasis on the dosage and the duration of their misbalance.
Databáze: Directory of Open Access Journals