Coagulation Factor Activity and Hemostatic Markers of Endothelial Dysfunction in Patients with Peripheral Arterial Disease

Autor:	Roman E. Kalinin, Igor A. Suchkov, Nina D. Mzhavanadze, Olga N. Zhurina, Emma A. Klimentova, Vladislav O. Povarov
Jazyk:	English<br />Korean
Rok vydání:	2021
Předmět:	hemostasis vascular endothelium thrombosis endovascular procedures peripheral arterial disease Diseases of the blood and blood-forming organs RC633-647.5 Diseases of the circulatory (Cardiovascular) system RC666-701
Zdroj:	Vascular Specialist International, Vol 37 (2021)
Druh dokumentu:	article
ISSN:	2288-7970 2288-7989
DOI:	10.5758/vsi.210010
Popis:	Purpose: We aimed to evaluate the impact of intrinsic coagulation factors and hemostatic markers of endothelial dysfunction on complications in patients with atherosclerotic peripheral arterial disease (PAD). Materials and Methods : This prospective study enrolled 120 PAD patients at Fontaine stages 2b to 3 who underwent open surgical, endovascular, or conservative treatment. Coagulation factors (FVIII, FIX, and FXI) and endothelial hemostatic markers, including von Willebrand factor (vWF) activity and level, soluble endothelial protein C receptor, and plasminogen activator inhibitor-1 (PAI-1) levels, were assessed. Results : At 3 months after open bypass grafting, activity of FVIII significantly increased from a median of 175% to 233% (P
Databáze:	Directory of Open Access Journals
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