A high-resolution real-time quantification of astrocyte cytokine secretion under shear stress for investigating hydrocephalus shunt failure

Autor: Fatemeh Khodadadei, Allen P. Liu, Carolyn A. Harris
Jazyk: angličtina
Rok vydání: 2021
Předmět:
Zdroj: Communications Biology, Vol 4, Iss 1, Pp 1-10 (2021)
Druh dokumentu: article
ISSN: 2399-3642
DOI: 10.1038/s42003-021-01888-7
Popis: Khodadadei et al. investigate the mechanisms underlying cerebral shunt failure using a microfluidic chip to simulate shear forces in the shunt. Employing total internal reflection fluorescence imaging, their findings indicate that astrocyte interleukin-6 cytokine secretions increase under higher shunt shear stresses, informing future shunt design and potential drug therapies to reduce shunt failure in patients.
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