The Role of COVID-19 Vaccination in Serological and Infectious Response in the Xokós Indigenous Community

Autor: Eloia Emanuelly Dias Silva, Marina dos Santos Barreto, Ronaldy Santana Santos, Deise Maria Rego Rodrigues Silva, Pedro Henrique Macedo Moura, Pamela Chaves de Jesus, Jessiane Bispo de Souza, Adriana Gibara Guimarães, Lucas Alves da Mota Santana, Lysandro Pinto Borges
Jazyk: angličtina
Rok vydání: 2024
Předmět:
Zdroj: COVID, Vol 4, Iss 9, Pp 1476-1484 (2024)
Druh dokumentu: article
ISSN: 2673-8112
DOI: 10.3390/covid4090104
Popis: Objectives: This study aims to examine the serological and infectious characteristics of the Xokós indigenous community in Brazil, both prior to and following COVID-19 immunization; Methods: Immunofluorescence assays were employed to identify the SARS-CoV-2 viral antigen, while IgM and IgG antibody tests for COVID-19 were utilized to assess the participants’ infectious and serological profiles in July 2020, before the commencement of the COVID-19 vaccination campaign, and in March 2022, during the booster dose vaccination campaign; Results: The majority of participants (n = 22) were female, with an average age of 42.20 years. The most prevalent comorbidity was hypertension (60%; n = 9), followed by hypertension associated with diabetes (20%; n = 3). No statistically significant correlation was found between the timing of vaccination and the levels of antigens or IgM. However, the prevalence of reactive antigens and IgM was 13.3% (n = 4) in the pre-vaccination group and 3.3% (n = 1) in the post-vaccination group. A statistically significant difference in IgG production was observed before and after vaccination (χ2(1) = 39.095, p < 0.01), as well as differences in IgG antibody detection before and after vaccination and in the vaccines used. Participants showed a higher probability of reactive IgG antibodies following vaccination; Conclusions: Our data demonstrate the beneficial effects of vaccination on the indigenous community, highlighting that continued immunization is a crucial step in protecting indigenous health and preventing severe outbreaks and deaths associated with the disease.
Databáze: Directory of Open Access Journals
Externí odkaz:
Nepřihlášeným uživatelům se plný text nezobrazuje