Flow chamber and microfluidic approaches for measuring thrombus formation in genetic bleeding disorders

Autor: Rogier M. Schoeman, Marcus Lehmann, Keith B. Neeves
Jazyk: angličtina
Rok vydání: 2017
Předmět:
Zdroj: Platelets, Vol 28, Iss 5, Pp 463-471 (2017)
Druh dokumentu: article
ISSN: 0953-7104
1369-1635
09537104
DOI: 10.1080/09537104.2017.1306042
Popis: Platelet adhesion and aggregation, coagulation, fibrin formation, and fibrinolysis are regulated by the forces and flows imposed by blood at the site of a vascular injury. Flow chambers designed to observe these events are an indispensable part of doing hemostasis and thrombosis research, especially with human blood. Microfluidic methods have provided the flexibility to design flow chambers with complex geometries and features that more closely mimic the anatomy and physiology of blood vessels. Additionally, microfluidic systems with integrated optics and/or pressure sensors and on-board signal processing could transform what have been primarily research tools into clinical assays. Here, we describe a historical review of how flow-based approaches have informed biophysical mechanisms in genetic bleeding disorders, challenges and potential solutions for developing models of bleeding in vitro, and outstanding issues that need to be addressed prior to their use in clinical settings.
Databáze: Directory of Open Access Journals
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