| Autor: |
Yupei LIU, Yingyu ZHANG, Zhen WEI, Jiameng LIU, Jing SUN, Bei FAN, Qiong WANG, Cong LU, Xinmin LIU, Fengzhong WANG |
| Jazyk: |
čínština |
| Rok vydání: |
2023 |
| Předmět: |
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| Zdroj: |
Shipin gongye ke-ji, Vol 44, Iss 2, Pp 400-407 (2023) |
| Druh dokumentu: |
article |
| ISSN: |
1002-0306 |
| DOI: |
10.13386/j.issn1002-0306.2022030217 |
| Popis: |
Objective: To study the preventive effect and the related mechanisms of polysaccharide of Polygonati Rhizoma (PSP) on cognitive impairments induced by sleep interruption (SI) in mice. Methods: The 72 ICR mice were randomly divided into the control group, the SI model group, the positive control (ginkgo biloba extract) group and the PSP (100, 200, 400 mg/kg) groups. After 14 days of pretreatment, all groups except the control group received sleep interruption which lasted for 14 days. Thereafter, the behavioral tests were performed by using the open field test, the object recognition experiment, the Morris water maze task and the passive avoidance test. Following the behavioral tests, the biochemical analysis was conducted by measuring the levels of IL-1β and IL-6 in the serum and the hippocampus, the contents of GABA and Ach in the hippocampus. Results: The open field test result showed, there were no significant changes in the locomotor activities of mice among all groups (P>0.05). Compared with the SI model group, SPS (100, 200, 400 mg∙kg−1) treatment markedly elevating discrimination index (DI) in object recognition experiment (P |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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