Optimization of an Analytical Method for Indoxacarb Residues in Fourteen Medicinal Herbs Using GC–μECD, GC–MS/MS and LC–MS/MS

Autor: Hun-Ju Ham, Syed Wasim Sardar, Abd Elaziz Sulieman Ahmed Ishag, Jeong-Yoon Choi, Jang-Hyun Hur
Jazyk: angličtina
Rok vydání: 2022
Předmět:
Zdroj: Separations, Vol 9, Iss 9, p 232 (2022)
Druh dokumentu: article
ISSN: 2297-8739
DOI: 10.3390/separations9090232
Popis: Pesticide residue analysis in medicinal herbs is a challenging task because of the matrix effect and its influence on quantitative analysis despite the continuous development of several new analytical methods and instrumentations. In this study, a modified QuEChERS method was developed for the analysis of indoxacarb residue in medicinal herbs by using the conventional instrument, gas chromatography micro-electron-capture-detector (GC–μECD), and comparing it with gas chromatography–tandem mass spectrometry (GC–MS/MS) and liquid chromatography–tandem mass spectrometry (LC–MS/MS). Samples were extracted with acetonitrile and purified using an NH2 cartridge. The optimized method efficiently removes the co-extractives and offered a limit of quantification of 0.01 mg kg−1. The GC–μECD analysis results of indoxacarb in seven medicinal herbs out of fourteen species at a fortification level of 0.01 mg kg−1 showed a recovery range of 79.7–117.6%, while the rest showed recovery > 120%. Similarly, the recovery of indoxacarb by GC and LC–MS/SM were 74.1–105.9 and 73.0–99.0%, respectively, with a relative standard deviation of ±20%. Whereas the results for LC–MS/MS were
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