Expression deregulation of matrix metalloproteinases and vasoconstriction related genes in Pakistani females with abnormal uterine bleeding

Autor:	Zertashia Akram, Ishrat Mahjabeen, Faiza Irshad, Malik Waqar Ahmed, Sadaf Rehman, Muhammad Rizwan, Amna Shafqat, Aniqa Kiran, Asma Saeed
Jazyk:	angličtina
Rok vydání:	2022
Předmět:	Abnormal uterine bleeding Extracellular matrix Menstruation Miscarriages Gynecology and obstetrics RG1-991 Public aspects of medicine RA1-1270
Zdroj:	BMC Women's Health, Vol 22, Iss 1, Pp 1-11 (2022)
Druh dokumentu:	article
ISSN:	1472-6874
DOI:	10.1186/s12905-022-02132-y
Popis:	Abstract Background Abnormal uterine bleeding (AUB) is irregular menstrual bleeding which has great impact on female health and life style. Various genetic factors are involved in etiology and pathology of AUB. Present study was designed to explore the association of PTGFR, MMP9, MMP2, TGFB3 and VEGFB with AUB. Methods Blood samples of 212 females with AUB were collected along with age-matched healthy control. Expression variation of targeted genes was evaluated using qPCR. Present study cohort was divided into different groups based on demographic parameters and all targeted genes were correlated with study demographics. Results Expression of targeted genes was significantly (P 9 days bleeding compared to AUB patient had 60 kg body weigh compared to AUB patient with
Databáze:	Directory of Open Access Journals
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