Energy Metabolism as a Therapeutic Target in Cancer: The Role of Coenzyme Q10

Autor: David Mantle, Hannah Rowbottom, Jacob Jones, Indiia Margarita Potts, Nadia Turton, Mollie Dewsbury, Guillermo Lopez-Lluch, Iain P. Hargreaves
Jazyk: angličtina
Rok vydání: 2024
Předmět:
Zdroj: Oxygen, Vol 4, Iss 2, Pp 122-138 (2024)
Druh dokumentu: article
ISSN: 2673-9801
DOI: 10.3390/oxygen4020008
Popis: The generation of energy within cells is a fundamental process enabling cell survival, and as such it represents a potential target in cancer therapy. In this article, we therefore review the relative contributions of glycolysis and oxidative phosphorylation/mitochondrial function to cancer cell energy generation, and we highlight their respective potential value as chemotherapeutic targets. This article is particularly focussed on the potential role of coenzyme Q10 in the prevention and treatment of cancer.
Databáze: Directory of Open Access Journals