Immune Activation and HIV-1 Viraemia In an Asymptomatic Paediatric Patient
| Autor: | Zaknun D., Neugebauer J., Soelder B., Dierich M.P., Wachter H., Fuchs D. |
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| Jazyk: | angličtina |
| Rok vydání: | 1994 |
| Předmět: | |
| Zdroj: | Pteridines, Vol 5, Iss 4, Pp 136-138 (1994) |
| Druh dokumentu: | article |
| ISSN: | 0933-4807 2195-4720 |
| DOI: | 10.1515/pteridines.1994.5.4.136 |
| Popis: | Immune stimulation due to secondary infection may enhance HIV replication and viraemia, since cellular activation of CD4+T-cells is required for viral replication. We describe a case of an 18 months old child, exposed intrauterinely to human immunodeficiency virus type 1 (HIV -1). During a period of various infections, which was followed by transient viraemia, decrease of CD4 + T -lymphocytes and increase of neopterin concentrations was registered. Disease progression may have occured due to activation of latent HIV-l in CD4+ T -lymphocytes/macrophages by secondary infections. |
| Databáze: | Directory of Open Access Journals |
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