Acute Myeloid Leukemia Presenting as Myeloid Sarcoma with a Predisposition to the Gynecologic Tract

Autor: Ryan M. Kahn, Sushmita Gordhandas, Eloise Chapman-Davis, Elizabeth Margolskee, Cathleen Matrai, Amy Chadburn, Ellen Ritchie
Jazyk: angličtina
Rok vydání: 2019
Předmět:
Zdroj: Case Reports in Oncological Medicine, Vol 2019 (2019)
Druh dokumentu: article
ISSN: 2090-6706
2090-6714
DOI: 10.1155/2019/4189275
Popis: Myeloid sarcoma (MS) is a rare, extramedullary tumor consisting of immature white blood cells of myeloid lineage. MS is usually associated with the concurrent diagnosis of acute myeloid leukemia (AML) but can also present in the absence of bone marrow disease or at relapse of AML. MS of the gynecologic tract is exceedingly rare; however, it is hypothesized that it is likely more prevalent than previously understood given postmortem findings and persistence in preserved ovarian tissue. There is minimal literature surrounding MS and extramedullary relapse with no clear guidelines. This is a case report of a 48-year-old woman with MS involving the uterine corpus, fallopian tubes, and left ovary followed by a literature review. The overall aim is to review data regarding leukemic immune evasion and sanctuary sites in order to raise awareness as this represents an important and underrecognized hematologic malignancy in an often misdiagnosed, underrecognized site.
Databáze: Directory of Open Access Journals
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