Disubstituted 4-Chloro-3-nitrophenylthiourea Derivatives: Antimicrobial and Cytotoxic Studies

Autor:	Anna Bielenica, Giuseppina Sanna, Silvia Madeddu, Gabriele Giliberti, Joanna Stefańska, Anna E. Kozioł, Oleksandra Savchenko, Paulina Strzyga-Łach, Alicja Chrzanowska, Grażyna Kubiak-Tomaszewska, Marta Struga
Jazyk:	angličtina
Rok vydání:	2018
Předmět:	antimicrobial activity biofilm cytotoxicity thiourea derivatives X-ray crystallography Organic chemistry QD241-441
Zdroj:	Molecules, Vol 23, Iss 10, p 2428 (2018)
Druh dokumentu:	article
ISSN:	1420-3049
DOI:	10.3390/molecules23102428
Popis:	4-Chloro-3-nitrophenylthioureas 1–30 were synthesized and tested for their antimicrobial and cytotoxic activities. Compounds exhibited high to moderate antistaphylococcal activity against both standard and clinical strains (MIC values 2–64 μg/mL). Among them derivatives with electron-donating alkyl substituents at the phenyl ring were the most promising. Moreover, compounds 1–6 and 8–19 were cytotoxic against MT-4 cells and various other cell lines derived from human hematological tumors (CC50 ≤ 10 μM). The influence of derivatives 11, 13 and 25 on viability, mortality and the growth rate of immortalized human keratinocytes (HaCaT) was observed.
Databáze:	Directory of Open Access Journals
Externí odkaz:	https://doaj.org/article/6a5e4fdbc088440281608bfbd13f9a5b Zobrazit plný text záznamu View record in DOAJ Plný text ve formátu PDF Plný text ve formátu HTML
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