Alveolar macrophage metabolic programming via a C-type lectin receptor protects against lipo-toxicity and cell death

Autor: Michal Scur, Ahmad Bakur Mahmoud, Sayanti Dey, Farah Abdalbarri, Iona Stylianides, Daniel Medina-Luna, Gayani S. Gamage, Aaron Woblistin, Alexa N. M. Wilson, Haggag S. Zein, Ashley Stueck, Andrew Wight, Oscar A. Aguilar, Francesca Di Cara, Brendon D. Parsons, Mir Munir A. Rahim, James R. Carlyle, Andrew P. Makrigiannis
Jazyk: angličtina
Rok vydání: 2022
Předmět:
Zdroj: Nature Communications, Vol 13, Iss 1, Pp 1-20 (2022)
Druh dokumentu: article
ISSN: 2041-1723
DOI: 10.1038/s41467-022-34935-w
Popis: Alveolar macrophages (AM) in the lungs maintain surfactant during homeostasis and respond to infectious pathogens. Here the authors show that in the absence of NKR-P1B, pneumococcal infection is more severe because KO AM have increased rates of lipid surfactant uptake and reduced anti-microbial function.
Databáze: Directory of Open Access Journals
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