Role of Cannabinoid Receptors in Memory Storage

Autor: Robert E. Hampson, Sam A. Deadwyler
Jazyk: angličtina
Rok vydání: 1998
Předmět:
Zdroj: Neurobiology of Disease, Vol 5, Iss 6, Pp 474-482 (1998)
Druh dokumentu: article
ISSN: 1095-953X
14982870
DOI: 10.1006/nbdi.1998.0223
Popis: Studies have shown that Δ9-tetrahydrocannabinol, the principal psychoactive ingredient in marijuana, produces memory deficits similar to those produced by neurochemical lesions of the hippocampus. Such lesions impair performance in short-term spatial memory tasks learned prior to the lesion. Animals trained in the behavioral task following the lesion can still perform the task, but learn a different behavioral strategy. Cannabinoid agonists impair behavioral performance in a delay-dependent manner similar to that produced by lesions, but also shift the behavioral response strategy. A possible role for cannabinoid receptors and endogenous cannabinoids may thus be to regulate the storage (i.e., encoding) of information, as well as the means by which that information is retrieved.
Databáze: Directory of Open Access Journals
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