Toxic Effects of Carbaryl Exposure on Juvenile Asian Seabass (Lates calcarifer)

Autor: Junhua Huang, Zhengyi Fu, Wei Yu, Zemin Bai, Zhenhua Ma
Jazyk: angličtina
Rok vydání: 2024
Předmět:
Zdroj: Journal of Xenobiotics, Vol 14, Iss 3, Pp 923-938 (2024)
Druh dokumentu: article
ISSN: 2039-4713
2039-4705
DOI: 10.3390/jox14030051
Popis: This study examines the physiological and immunological effects of 0.5 ppm carbaryl exposure on juvenile Asian seabass (Lates calcarifer) over 12 h to 72 h. Notable results include decreased activities of liver enzymes catalase (CAT), lactate dehydrogenase (LDH), and glutathione peroxidase (GSH-PX), while superoxide dismutase (SOD) levels remained stable, with the lowest activities of CAT and GSH-PX observed at 72 h. Serum biochemistry revealed increased alkaline phosphatase (AKP) and acid phosphatase (ACP) at 24 h, with declining aspartate aminotransferase (AST) and a peak in creatinine at 48 h. Histopathological analysis showed carbaryl-induced necrosis in liver and spleen cells, and increased melanomacrophage centers in both organs. Additionally, immune gene expression analysis indicated an upregulation of heat shock proteins and consistent elevation of complement component C3 and interleukin-8 (IL-8). These findings suggest that carbaryl exposure significantly impairs organ function and modulates immune responses in L. calcarifer, underlining the need for further research on protective strategies against pesticide impacts in aquaculture.
Databáze: Directory of Open Access Journals
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