The Effect of Eight Weeks of High-Intensity Interval Training on Follistatin Gene Expression in the Fast and Slow Twitch Muscles of Rats with Myocardial Infarction
| Autor: | Edris Ramezani, Mehran Ghahramani, Hadi Ghaedi |
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| Jazyk: | angličtina |
| Rok vydání: | 2024 |
| Předmět: | |
| Zdroj: | Iranian Journal of Medical Sciences, Vol 49, Iss 11, Pp 716-723 (2024) |
| Druh dokumentu: | article |
| ISSN: | 0253-0716 1735-3688 |
| DOI: | 10.30476/ijms.2024.99387.3141 |
| Popis: | Background: Myocardial infarction causes mitochondrial atrophy and loss of function by reducing mitochondrial volume. Therefore, researchers are interested in finding a way to reduce the injuries and treat them. The study aims to evaluate the effect of 8 weeks of high-intensity interval training on follistatin (FST) gene expression in the fast and slow twitch muscles of rats with myocardial infarction. Methods: The study was conducted in 2020 at the Cardiac Research Center, Shahid Rajaei University of Medical Sciences (Tehran, Iran). For this purpose, 12 male Wistar rats with myocardial infarction were assigned to the experimental group high-intensity interval training (3 days a week for 30 min, each interval consisting of 4 min of running with 85-90% VO2max intensity and 2 min of active recovery with intensity of 50-60% VO2max for 8 weeks) and a control group. Then, the expression of follistatin in fast and slow twitch muscle contraction genes was investigated as triggers and inhibitors of muscle atrophy. Statistical data were analyzed with SPSS18 (α≥0.05). To determine the normality of the data, the Kolmogorov-Smirnov test was used, and in the case of normality of the data distribution, the independent samples t test was used.Results: Independent t test results showed that FST gene expression in the slow twitch (ST) muscle contraction group was significantly decreased compared with the control group (P |
| Databáze: | Directory of Open Access Journals |
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