| Autor: |
Zhenhui Wang, Zhanlin Li, Chao Niu, Lanping Yang, Yangyang Zhai, Dehai Li, Guangwei Wu, Zhenzhen Zhang, Xueqian He |
| Jazyk: |
angličtina |
| Rok vydání: |
2023 |
| Předmět: |
|
| Zdroj: |
Frontiers in Microbiology, Vol 14 (2023) |
| Druh dokumentu: |
article |
| ISSN: |
1664-302X |
| DOI: |
10.3389/fmicb.2023.1200680 |
| Popis: |
Introduction and MethodsSilencing gene activation can effectively enrich the diversity of fungal secondary metabolites.Results and DiscussionCultivation of the Yellow River wetland-derived fungus Talaromyces funiculosus HPU-Y01 with aniline led to the isolation of one new aniline-containing polyketide tanicutone A (1), two new bicyclic polyketides tanicutones B-C (2–3), a new related trienoic acid 8-methyldeca-2,4,6-trienoic acid (5), and a known compound 4. The planar structures and configurations of 1–5 were determined by NMR, MS, and ECD calculations. Compound 2 featured a key aldehyde group and showed promising inhibitory activity against Vibrio parahaemolyticus with a minimum inhibitory concentration (MIC) value of 0.17 μg/mL. This is a rare report of aniline-induced fungal production of tetrahydronaphthone polyketides. |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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