| Autor: |
Victoria Cairoli, Marcela De Sousa, Jean Carla Sejas, María Victoria Preciado, Pamela Valva |
| Jazyk: |
angličtina |
| Rok vydání: |
2024 |
| Předmět: |
|
| Zdroj: |
Annals of Hepatology, Vol 29, Iss , Pp 101655- (2024) |
| Druh dokumentu: |
article |
| ISSN: |
1665-2681 |
| DOI: |
10.1016/j.aohep.2024.101655 |
| Popis: |
Conflict of interest: No Introduction and Objectives: Liver fibrosis evaluation is essential in management of chronic hepatitis C (CHC). Extracellular vesicles (EVs) are essential components of liquid biopsy. MicroRNAs (miRNAs) within EVs could serve as biomarkers of damage due to their role in regulating fibrogenesis through gene expression modulation. The objective was: evaluate plasma derived (p)EVs-miRNAs as biomarkers of significant fibrosis (F≥2) in CHC. Patients / Materials and Methods: pEVs were isolated using exoRNeasy kit (QIAGEN) from 50 CHC cases (36% F≥2, assessed by liver fibrosis). miRNA-enriched RNA was extracted, sequenced by NGS and significant differential expression (SDE) analysis was performed between F≥2 and F |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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