Fatal Spontaneous Tumor Lysis Syndrome in a Patient with Metastatic Colon Cancer: A Clinical Case of Rare Oncological Emergency

Autor:	Inna Shaforostova, Robert Fiedler, Martina Zander, Johannes Pflumm, Wolfgang Josef März
Jazyk:	angličtina
Rok vydání:	2020
Předmět:	tumor lysis syndrome colon cancer spontaneous tumor lysis syndrome Diseases of the digestive system. Gastroenterology RC799-869
Zdroj:	Case Reports in Gastroenterology, Vol 14, Iss 2, Pp 255-260 (2020)
Druh dokumentu:	article
ISSN:	1662-0631
DOI:	10.1159/000507648
Popis:	Tumor lysis syndrome (TLS) is a potentially life-threatening complication of chemotherapy. It usually occurs in rapidly proliferating hematological malignancies. TLS is deemed spontaneous (STLS) when it occurs prior to any cytotoxic or definite treatment. STLS is extremely rare in solid tumors. Here, we report a rare case of fatal STLS in a 47-year-old woman diagnosed with metastatic colon cancer. The patient developed acute renal failure with anuria, electrolyte disturbances, and metabolic acidosis before initiating chemotherapy. Despite appropriate management of TLS, including renal replacement therapy, she died within a few days from multiorgan failure. Only few other case reports of STLS associated with colon cancer have been reported in the literature.
Databáze:	Directory of Open Access Journals
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