| Autor: |
Lan-Yuan Zhang, Andrew Y. Kim, Joseph F. Cheer |
| Jazyk: |
angličtina |
| Rok vydání: |
2022 |
| Předmět: |
|
| Zdroj: |
Addiction Neuroscience, Vol 3, Iss , Pp 100022- (2022) |
| Druh dokumentu: |
article |
| ISSN: |
2772-3925 |
| DOI: |
10.1016/j.addicn.2022.100022 |
| Popis: |
Cannabinoid type 1 receptors (CB1Rs) orchestrate brain reward circuitry and are prevalent neurobiological targets for endocannabinoids and cannabis in the mammalian brain. Decades of histological and electrophysiological studies have established CB1R as presynaptic G-protein coupled receptors (GPCRs) that inhibit neurotransmitter release through retrograde signaling mechanisms. Recent seminal work demonstrates CB1R expression on astrocytes and the pivotal function of glial cells in endocannabinoid-mediated modulation of neuron-astrocyte signaling. Here, we review key facets of CB1R-mediated astroglia regulation of synaptic glutamate transmission in the nucleus accumbens with a specific emphasis on cocaine-directed behaviors. |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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