Platelet activation and neutrophil extracellular trap (NET) formation in immune thrombocytopenia: is there an association?
| Autor: | Maria L Lozano, Lamya Garabet, Maria Piedad Fernandez-Perez, Ascension M De Los Reyes-García, Pedro Diaz-Lozano, Nuria Garcia-Barbera, Sonia Aguila, Vicente Vicente, Waleed Ghanima, Constantino Martinez, Rocio Gonzalez-Conejero |
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| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: | |
| Zdroj: | Platelets, Vol 31, Iss 7, Pp 906-912 (2020) |
| Druh dokumentu: | article |
| ISSN: | 0953-7104 1369-1635 09537104 |
| DOI: | 10.1080/09537104.2019.1696456 |
| Popis: | No biological predictors for the increased risk of thrombosis in patients with immune thrombocytopenia (ITP) have been identified. The aim of the study was to investigate platelet and neutrophil activation as well neutrophil extracellular trap (NET) formation in 63 ITP patients and 30 healthy volunteers. Platelet and neutrophil activation was assessed during steady state using flow cytometry analysis, and NETs were evaluated by quantitation of cell free DNA (cfDNA), and citrullinated histone-3-DNA (CitH3-DNA). Patient platelets and neutrophils showed increased CD62 and CD11b expression compared to controls (p = .038, and p = .022, respectively). In patients, platelet activation inversely correlated with platelet count and platelet size (p |
| Databáze: | Directory of Open Access Journals |
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