Cerebrospinal Fluid Biomarkers in Parkinson’s Disease: A Critical Overview of the Literature and Meta-Analyses

Autor:	Takayuki Katayama, Jun Sawada, Kae Takahashi, Osamu Yahara
Jazyk:	angličtina
Rok vydání:	2020
Předmět:	Parkinson’s disease cerebrospinal fluid α-synuclein amyloid β42 tau neurofilament light chain Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571
Zdroj:	Brain Sciences, Vol 10, Iss 7, p 466 (2020)
Druh dokumentu:	article
ISSN:	2076-3425
DOI:	10.3390/brainsci10070466
Popis:	Parkinson’s disease (PD) is a common neurodegenerative disorder; however, well-established biochemical markers have not yet been identified. This review article covers several candidate cerebrospinal fluid (CSF) biomarkers for PD based on the recent literature and meta-analysis data. The decrease of α-synuclein in PD is supported by meta-analyses with modest reproducibility, and a decrease of amyloid β42 is seen as a prognostic marker for cognitive decline. Tau, phosphorylated tau (p-tau), and neurofilament light chains have been used to discriminate PD from other neurodegenerative disorders. This article also describes more hopeful biochemical markers, such as neurotransmitters, oxidative stress markers, and other candidate biomarkers.
Databáze:	Directory of Open Access Journals
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